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The lessexible MDMX interacts with the more mobile p53, because the peptide canadapt different conformations to dock to MDMX, albeit with a reduced afnity.Nutlin, however, is rigid and hence can only interact with MDMX with low afn -ity . (2007) Pathophysiology of REM sleep behaviordisorder and relevance to neurodegenerative disease. Risksof treatment and no treatment depend on many patient-specific and aneurysm-specific factors, including aneu-rysm size, location, and morphology and the patient’s ageand medical comorbidities. (2004) Pathologicalinvestigation of essential tremor. (2010) Variably protease-sensitive prion-opathy: a new sporadic disease of the prion protein. This includes severe and remarkable tachycardia, arrhythmias, andhypertension that fluctuate wildly. Studies of individualsexposed to TCDD chronically in Times Beach, Missourihave revealed a few differences from a control populationin some parameters, but overall the observations do notsuggest significantly altered immunocompetence. (1990) Clinical diagnosis ofBinswanger’s disease.